What Prescription Drugs Interact with Magnesium

Posted by Fruit Of Spirit on

What Prescription Drugs Interact with Magnesium

What prescription drugs interact with magnesium? Magnesium is an essential nutrient for the body, necessary for the normal functioning of bone structure in the body. Usually, people fulfill their magnesium requirement through diet in a natural way. However, it is not enough magnesium supplements are also available.

Magnesium deficiency can result in numerous health disorders like osteoporosis, high blood pressure, heart issues, diabetes, and clogged arteries are to name a few. Moreover, you can also take magnesium as a laxative for constipation or the preparation of bowel movement. Sometimes it is used as an antacid for acid indigestion.

There are several uses of magnesium and is an essential ingredient for the normal functioning of the body. You can either take magnesium orally, as an injection or as a cream to apply on skin. But the important thing is how magnesium will interact with other prescribed drugs. So in this article, we will study what prescription drugs interact with magnesium.  


Prescription Drug Interaction with Magnesium

Below is the interaction of magnesium with other drugs:

  • Antibiotic Aminoglycoside Interaction with Magnesium:

Antibiotics that affect muscles are named as aminoglycosides. And we all know that magnesium also affects muscles. Amikacin (Amikin), kanamycin (Kantrex), tobramycin (Nebcin), gentamicin (Garamycin), and streptomycin are, to name a few of the aminoglycosides.

If you use these medicines along with magnesium shots, it might result in muscle problems. Therefore, always take your doctor's opinion first before using them together. If it is really necessary to take these two together, then try to use them in a moderate amount.

  • Antibiotics Quinolone Interaction with Magnesium:

There are certain antibiotics like Quinolone; when you take magnesium with them, it can reduce the amount of antibiotics absorbed by the body. Some of the common Quinolone antibiotics include norfloxacin (Chibrxin, Noroxin), trovafloxacin (Trovan), ciprofloxacin (Cipro), grepafloxacin (Raxar) and enoxacin (Penetrex).

Never take thee antibiotics along with magnesium. Instead, the best approach is to either take antibiotics 2 hours before magnesium or 4 to 6 hours after magnesium consumption. Moreover, consult with your physician for better advice.  

  • Antibiotic Tetracycline Interaction with Magnesium:

The next prescription drug interaction with magnesium is Tetracycline, another antibiotic. When you consume tetracycline and magnesium supplements simultaneously, they can attach in the stomach. As a result of which the amount of tetracycline absorbed in the body will be reduced significantly.

Therefore, it is better to avoid this combination by either taking magnesium 2 hours before or 4 hours after intake of tetracycline. Common tetracycline includes minocycline (Minocin), tetracycline (Achromycin), and demeclocycline (Declomycin). So, always be cautious with this combination.

  • Bisphosphonate Interaction with Magnesium:

You should also be cautious about the interaction of magnesium with a bisphosphonate. Because when you take bisphosphonate along with magnesium supplements, magnesium will reduce the effectiveness of bisphosphonate. I have already mentioned twice, and I will mention again consult your doctor first when taking them.

Therefore, like antibiotics, always take bisphosphonate 2 hours before magnesium consumption or the next day after taking magnesium supplements. Risedronate (Actonel), alendronate (Fosamax), tiludronate (Skelid), and etidronate (Didronel) are some of the common bisphosphonate drugs.

  • High Blood Pressure Medication Interaction with Magnesium:

Next in the list is the high blood pressure supplement as a calcium channel blockers (blocking the entry of calcium in cells). However, magnesium is known for its properties to lower blood pressure. Therefore, if you take high blood pressure medications and magnesium, it can cause your blood pressure to drop too low.

Common high blood pressure drugs include isradipine (DynaCirc), verapamil (Calan, Isoptin, and Verelan), felodipine (Plendil), nifedipine (Adalat and Procardia), diltiazem (Cardizem) and amlodipine (Norvasc). So it is precarious to take magnesium along with high blood pressure medicines.

Hypertension, High Blood Pressure

  • Muscle Relaxant Interaction with Magnesium:

If you have learned about the magnesium benefits, it acts as a natural muscle relaxant. And we all know muscle relaxant drugs' goal is to relax your muscles and ease muscle pain and cramping. However, it is not a good idea to take magnesium with muscle relaxants.

Taking both of them together might activate muscle relaxants' side effects, thus causing other health issues. So, it is better to avoid this combo. Common muscle relaxants are carisoprodol (Soma), pipecuronium (Arduan), gallamine (Flaxedil), succinylcholine (Anectine), cyclobenzaprine, atracurium (Tracrium) and pancuronium (Pavulon).

  • Water Pills Interaction with Magnesium:

Water pills or potassium-sparing diuretics are used to increase the level of magnesium in the body. Therefore, if you take magnesium in the presence of water, pills can result in too much magnesium accumulation in the body. And we know that too much of anything can cause harm. Therefore, the same is the rule with excess magnesium accumulation.

So, don't take these two together to avoid any side effects. Water pills that are known to increase the level of calcium in the body are triamterene (Dyrenium), amiloride (Midamor), and spironolactone (Aldactone).

  • Digoxin (Lanoxin) Interaction with Magnesium:

Digoxin (Lanoxin) is the drug for the heart to beat more strongly. On the other hand, there is also evidence that magnesium is effective for the heart and helps it beat properly. But when you take digoxin (Lanoxin) and magnesium together, magnesium can significantly reduce the amount of the digoxin absorbed by the body.

As a result of which when the body absorbs less digoxin (Lanoxin), digoxin (Lanoxin) might not be of much help for you. Therefore, this combo is not preferable, and you should avoid it at all costs.

  • Gabapentin (Neurontin) Interaction with Magnesium:

Gabapentin (Neurontin) is an anticonvulsant drug that helps to treat seizure and neuropathic pain. On the contrary, if you have a little know-how about magnesium benefits. It can help with cognitive abilities. But if you consume these two supplements together, magnesium can reduce gabapentin (Neurontin) absorption in the body.

Consequently, when your body absorbs a low amount of gabapentin (Neurontin), it will not show significant results. Therefore, the best approach is to take gabapentin (Neurontin) at least 2 hours before magnesium consumption or 4 to 6 hours after its intake.

Thermometer, Headache, Pain, Pills

  • Diabetes Medication Interaction with Magnesium:

It is another dangerous combo and takes your physician's advice first before using these two together. Diabetes medicines are usually sulfonylureas. Unlike other medicines in the case of diabetes, drug magnesium increases the number of sulfonylureas absorbed by the body. Thus a high amount of sulfonylureas can significantly reduce blood sugar resulting in lower than usual blood sugar.

Moreover, magnesium also reduces the amount of blood glucose. Therefore, taking these two together can significantly reduce the blood sugar level in some patients. Common sulfonylureas agents include acetohexamide, glimepiride, chlorpropamide, glibornuride, tolbutamide, glyclopyramide, and gliclazide.

  • Anticoagulant/ Antiplatelet Drugs Interaction with Magnesium:

When it comes to the interaction of magnesium with the anticoagulant or antiplatelet medicines, avoid this deadly combo. There is evidence that shows that magnesium can slow the blood clotting process. Thus if you take magnesium along with anticoagulants can increase the chances of bleeding and bruising.

Aspirin, enoxaparin (Lovenox), heparin, clopidogrel (Plavix), dalteparin (Fragmin), indomethacin (Indocin), warfarin (Coumadin) and ticlopidine (Ticlid) are famous anticoagulants. However, the best thing to do is to consult your doctor first for a professional opinion.

  • Antacids Interaction with Magnesium:

The last drug we have in the list is antacids that are used for stomach ache. Along with other ingredients, antacids already have magnesium in them. Therefore, the use of antacids with magnesium can reduce the laxative effects of magnesium. Consequently, those who are taking magnesium as a laxative might require a high dose of magnesium.

Some of the commonly used antacids include calcium carbonate (Tums), magnesium sulfate (Bilagog), magaldrate (Riopan), dihydroxy aluminum sodium carbonate (Rolaids) and aluminum hydroxide (Amphojel).


When discussing magnesium supplement interaction with other drugs, how can we ignore the correct dosage of magnesium? These dosages are scientifically proven and are for adults.


  • The daily magnesium requirement for age 19-30 is 400mg for men and 310mg for women. At the same time, those above 31years need 420mg (males) and 320mg (females). And for women aged between 14 and 18, this amount is 360mg.
  • For constipation, use 8.75-25g of magnesium citrate or 2.4-4.8g of magnesium sulfate.
  • In the case of indigestion, take 400-1200mg of magnesium hydroxide up to four times a day.
  • Take 3g of magnesium sulfate for hypomagnesemia and 5% solution of magnesium chloride.
  • Irregular heartbeat requires 2.163mg of magnesium-DL-hydrogen aspartate and 2.162mg of potassium-DL-hydrogen aspartate. Whereas, in the case of heart disease, use 800-1200mg of magnesium.
  • Diabetes calls for 2.5g of magnesium chloride in a 50ml solution.
  • Use magnesium hydroxide plus malic acid for fibromyalgia. Take 300mg of magnesium citrate.
  • In case of hearing loss, use 167mg of magnesium aspartate mixed in 200ml lemonade.
  • For high cholesterol, use 1g of magnesium oxide.
  • If you have weak and brittle bones, take 300-1800mg of magnesium hydroxide for six months daily.
  • If you suffer from PMS, take 333mg of magnesium oxide.

Final Words

In this article, we have discussed in detail what prescription drugs interact with magnesium. We study all drugs from high blood pressure to diabetes and from antibiotics to anticoagulants. So, it is better to avoid taking these drugs with magnesium. And lastly, always consult your physician first and ask for his advice if it is necessary to take both of them.


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