What Does L-Glutamine Do
L-Glutamine is an amino acid that is similar to glutamic acid. It is conditionally essential in the human body but acts as building block proteins. It is useful for humans in a lot of ways. It can benefit our digestive system, immune system, muscular system, protein synthesis, sugar carving, trauma, and many more aspects. It can be used as a dietary supplement. Also, it performs its functions in improving the stamina of the body. It can be useful in gaining weight.
Production of L-Glutamine
L-Glutamine is produced at an industrial scale with the help of Brevibacterium flavum bacteria. It gives a yield of almost 40 grams per liter in 2 days using a carbon source. It can also be synthesized by glutamine synthetase and ammonia. In the human body, 90% of L-Glutamine is produced in muscle tissues; however, it is also produced in our brain and lungs but a minimal amount. The liver also participates in the production, but it cannot be counted due to a minimum quantity.
L-Glutamine is present in many food items, like an egg, beef, skimmed milk, White rice, corn, dairy products, vegetables, and many more. However, a standard diet contains 3-6 grams of L-Glutamine. We can obtain L-Glutamine from different food sources that are
- Egg 0.6g
- Beef 4.8g
- Skim milk 8.1g
- Tofu 9.1g
- White Rice 11.1g
- Corn 16.2g
The above-illustrated quantities are per 100-gram consumption.
Working & beneficial Role of L-Glutamine
- Digestive system
It is considered one of the essential nutrients for our digestive system because it can maintain the intestinal walls' integrity. Its amino acids are also referred to as calming amino acids due to its relieving properties to our stomach. L-Glutamine quickly heals disturbed tissues of our digestive system. However, L-Glutamine is also useful for a patient who is suffering from bowel syndrome.
- In sugar cravings
L-Glutamine helps a lot in minimizing/eliminating the desire for blood sugar. Even its 500mg dosage thrice per day after meals is satisfactory for a sugar carving person. The theory behind this logic is that this amino is a protein building block and excess of protein cause reducing sugar.
In some diabetic type 2 patients, researchers say that 30 grams intake of glutamine reduces blood sugar to a great extent. Even some of the rehabilitation practitioners use L-Glutamine for alcohol carving persons.
- For immunity
Glutamine is essential for immune cells. It is required to improve the proliferation of lymphocytes and the production of macrophages. Glutamine presence boosts the activity of macrophages. As our intestine is the largest organ of our body, so it contains a lot of bacteria in it. Glutamine brings a lot of macrophages with him to fight against such bacteria.
Thus it is considered most important for our immune system. Not only this, but it also acts as a resistant barrier between leaky gut and internal walls of the intestine. It also provides at the spot energy to our immune system.
- For muscles
Due to its building block protein property, it is highly recommended in quick muscle gain. It has also been noted that a combination of glutamine with carbohydrates may give relief to the patient suffering from sewer fatigue. However, it provides relief for muscle soreness and provides quick recovery to our body's damaged muscle. It also acts as a pain reliever in our body for muscle. Wherever in our body where the muscle is pulled up, it immediately travels toward that region and gives instant relief. That is the reason why athletes prefer high glutamine intake to increase their stamina.
- In case of injury
L-Glutamine is considered as respiratory fuel because L-Glutamine contains metabolic fuel for both in vivo and in vitro conditions. It can increase cell proliferation. It can immediately enhance immune cell activity. It only changes its concentration at the site of injury, and lymphocyte starts moving toward that site giving us quick relief.
- In Sickle cell anemia
In the case of this disease, L-Glutamine is strongly recommended. Taking L-Glutamine twice a day orally can reduce a lot of symptoms of this disease.
- In burn
In the case of a burn, L-Glutamine is provided to the patient via a feeding tube. In this case, it reduces the chances of infection in burnt areas to a great extent. Studies also revealed that its usage decreased the number of deaths in burns cases. However, administrating it via IV may cause infection because possible patients might have suffered damage in veins from somewhere.
- in trauma
Trauma is actually a critical illness of a patient. Some scientific studies say that continuous usage of L-Glutamine can improve your health to a great extent. As L-Glutamine moves to our digestive system, all the macrophages and phagocytes start migrating toward this amino. This activity keeps moving bacteria outside our intestine.
- For HIV Patient
HIV patients have to suffer a lot of weight loss in this situation because they are unable to absorb food properly. In this case, L-Glutamine helps them a lot in the absorption of food. Some dietician dictates that taking this amino orally can help a lot to HIV patient. However, 40 grams per day is dosed prescribed best for a patient.
- In surgery after recovery
After surgeries, most of the patients do not take proper diet because due to some reason, however, if they take proper diet, they can reduce the period they have to spend at the hospital. In such a case, physicians recommend IV dose of L-Glutamine can help them a lot not only to meet their nutritional values but also to improve their immune system. It acts as a barrier at the site of surgery to stop invading bacteria from outside the body. It may also protect you from a hospital-acquired infection.
- Decreased ammonia patients
Studies reveal that lactulose interaction with L-Glutamine can increase the level of ammonia in patients of blood. It works on a simple mechanism. L-Glutamine is converted into blood ammonia
Benefits for Seizure patients
Some medications that are recommended by doctors to prevent seizures might affect chemicals that are necessary for our brain. In that case, L-Glutamine is recommended as an addition to these medicines. It helps in reducing the effect of these medicines to the brain.
Nutritional benefits in the human body
L-Glutamine is found to be most abundant in the human body. It can donate Nitrogen and carbon atoms wherever the body requires. That is why it is considered to be most important in nutrition. It can easily cross the blood-brain barrier that is the property of a few amino acids. It immediately precedes metabolism at the site where energy is required and provide energy. Most popular sites where immediate energy is needed are the brain, damaged muscle tissues, healing of the wound, sore areas, and in case of trauma.
L-Glutamine as a nitrogen source
According to a study, L-Glutamine supplies 35% of nitrogen of the body requirement. This will promote the production of protein in our body. High protein production prevents the breakage of muscles and protects them from pulling.
Some biochemical functions of L-Glutamine
- Protein synthesis
- Lipid synthesis
- Acid/Base level regulations in our body
- Cellular energy
- Donation of nitrogen
- Carbon donation
- Transportation of ammonia in the blood
Side effects of L-Glutamine
Despite all above-listed benefits, there are some drawbacks of the excess of L-Glutamine
- Nausea, Vomiting, Stomach pain, Gas
- Swelling in hands
- Muscle or joint pain
- Back pain
- Headache, dizziness, tired feeling
- Itching, rashes
- Dry mouth, runny nose, increase sweating.
Dosage of L-glutamine
On average, as a dietary supplement, 10 gram per day is recommended; however, this dose may vary from 5g to 30g per day. The best route recommended for L-Glutamine is oral intake.