Health Benefits of Ipriflavone

Posted by Wen Dan Jiang on

Health benefits of Ipriflavone

Ipriflavone is a drug that is used mostly for the treatment of bone diseases in women. The Ipriflavone drug is synthesized in a laboratory. It’s made from a substance called daidzein. Daidzein is obtained from the soy plant. Ipriflavone treats and prevents osteoporosis (weak bones), especially in old age women. It treats bone disease Paget's and prevents osteoporosis caused by certain medications and relieved the pain associated with osteoporosis. This drug is also used to increase metabolism. Bodybuilders usually use this drug to increase their metabolism.

What is Ipriflavone?

The formula of Ipriflavone is 7-isopropoxy-3-phenyl-4H-1-benzopyran-4-one, 147. Ipriflavone is derived from naturally occurring isoflavones. The chemical formula of it is C18H16O3. It is used to prevent osteoporosis, help in the maintenance of bone density and degrade bone resorption. This drug is prescribed too early postmenopausal women aged between 40 to 48 years.

After 12 months of this medicine intake, there will be a 1.1% improvement in bone density of the lumbar spine. After twenty-four months of treatment, bone density will improve up to 1.2 %.

Ipriflavone is devoid of estrogenicity as it does not induce secretion of LH in postmenopausal women. It can effectively improve bone density when combining with low doses of estrogens. It also interferes with osteoclast formation.

Ipriflavone allows the osteoblasts to formed the bone mass by slowing down the action of osteoclasts. Osteoclasts are bone-eroding cells. So when actions of these cells are slowed down, the bone-forming cells (osteoblasts) will easily build up bone mass.

Health benefits of Ipriflavone

  1. It proves as bone builders by many types of research 

Ipriflavone is proved as one of the best drugs that deal with bone diseases in recent times by many types of research. This drug increase bone density increases bone mass, and decreases bone deterioration. Ipriflavone drug helps in the prevention of osteoporosis. Osteoporosis is a skeletal disease characterized by accelerated deterioration of bone tissues and the low mass of bones.

The osteoporosis disease affected many people around the world, including twenty-eight million Americans and many more Europeans. The disease is most common in old age people and women. About 80% of European women are likely to developed osteoporosis diseases.

  1. Ipriflavone help in building new bones

The result of many experiment and research shows that ipriflavone accelerate the action of osteoblasts. It activates the action of osteoblast. The cellular process of bone mineral deposition and bone matrix protein forming is stimulated when osteoblasts interact with ipriflavone. The metabolites of ipriflavone decrease the activity of osteoclasts, which in result increase the activity of osteoblasts. Many clinical experiments on humans have shown that there is a significant increase in bone density due to the treatment of ipriflavone. The experiments also demonstrated that the activity of ipriflavone increases. It becomes more effective when administered with other bone support nutrients such as vitamin K, vitamin D, and calcium.

  1. Help in the prevention of fractures and bone loss

Ipriflavone was discovered in the 1930s. But due to lack of knowledge and its use, it did not become common or easily available to people. It was not manufactured in the laboratory until the 1970s due to a lack of knowledge about its use. Ipriflavone first experimented on animals in 1974. Then the experiment was conducted on humans in 1981.

It was recognized in the 1980s, and the 1990s that ipriflavone could decrease or prevent the loss of bone and is effective in the treatment of fractures of bones as a result of many placeboes, double-blind, and randomized experiments conducted on ipriflavone.

Many other kinds of research and experiments demonstrated that ipriflavone could increase bone density by up to 9 % during to 3 to 9 months of treatment by daily uptake of 600mg of it. It also helps in the reduction of fractures by two years of treatment.

There were five hundred patients treated with ipriflavone since then in the placebo and double-blind studies. These studies show that these patients gain about 5 to 7 % vertebral bone mineral density, the forearm, and the body. The researches also show that ipriflavone relieves the pain and increases the mobility of bones. Ipriflavone prevents loss of bones and fractures and more effective for postmenopausal women.

  1. Ipriflavone and MCHC

The most efficient and effective calcium that can be best used with ipriflavone is MCHC (Microcrystalline Hydroxyapatite). Microcrystalline Hydroxyapatite is known as an extract of bone. It contains all the minerals present in bones such as zinc, manganese, calcium, silica, magnesium, and other traces of minerals in natural ratios. MCHC also contains glycosaminoglycan and proteins.

  1. Helps in the reconstruction of bones

Experiments and researches demonstrated that Microcrystalline Hydroxyapatite is the only type of calcium that can help in the reconstruction of the bone when taken as a supplement. MCHC also helps in the restoration of bone loss. Due to this ability of MCHC, it becomes the best companion for ipriflavone. The MCHC not only decreased the loss of bone but also increased the cortical thickness of bones. This was proved when experiments were conducted on osteoporotic postmenopausal women having complications of basic biliary cirrhosis.

The experiments also demonstrated that patients taking MCHC, their bone thickness increases up to 6 %. It was also known from research that calcium gluconate does stop the bone loss, but it cannot restore the bone. If the patient stops taking the supplement of calcium gluconate, he/ she may suffer accelerated bone loss.

So, it is proved that MCHC and ipriflavone help reconstruct bones and increase the thickness of bones. MCHC is better than calcium carbonate, and calcium gluconate as MCHC has greater bioavailability and a high level of absorption.

MCHC is also helpful in the formation of bones. The patients taking MCHC experienced more rapid healing of fractures than those who do not take MCHC. Microcrystalline Hydroxyapatite also reduces the loss of bone in surgically induced postmenopausal women. MCHC also helps in the prevention of osteoporosis in rheumatoid arthritis patients. MCHC will more effective when patients take it with ipriflavone. The combination of both MCHC and ipriflavone rapidly reconstruct the bones.

  1. Ipriflavone's function and structure similar to the estrogen

As a result of much research, it has been found that both ipriflavone and estrogen have a similar chemical structure. Due to similar structures, ipriflavone mimics the action of estrogen on the prevention of loss of bones. Estrogens hormones inhibit the activity of osteoclasts that causes bone resorption.

Estrogen is an essential hormone in the human body that supports the skeletal structure of the body. The decreased in secretion from estrogen hormones leads to many bone diseases in older women. Women need to intake items of high calcium during an early age, so they don't face decreased estrogen hormones.

To the same structure, ipriflavone and estrogen serve the same structure. Ipriflavone is suggested to those women who have weak estrogen hormones, or their estrogen hormones are not properly functioning.

Ipriflavone does not show any same effects on the pituitary gland or hypothalamus as estrogens. The harmful estrogenic actions like stimulating uterine tissue of breasts are not affected by ipriflavone. These estrogenic actions are harmful to postmenopausal women. Ipriflavone does not show any side effects like these. It only prevents bone loss and helps in the improvement of the structure of bone.

  1. Stops the loss of bone

Osteoporosis is treated by decreasing the resorption of bone with the help of conventional drugs. About five to ten % of bone mass has been resorbed but not replaced at any given time. The density of bone can increase possibly up to five to ten % in a span of two or three years if resorption of bone is decreased. The hormonal therapy of using estrogen with progesterone can benefit postmenopausal women who have osteoporosis. The retardation of resorption of bone by estrogens results in the prevention of bone loss. This is most effective if the first year after menopause. Many drugs can treat osteoporosis, but they have many side effects. Some drugs which can treat osteoporosis are:

  • The drug sodium fluoride helps in increasing the density of the bone in the vertebra. But this drug is not effective in reducing the overall fracture of a vertebra.
  • A selective receptor modulator, like estrogen called Raloxifene, can be used in place of estrogen therapy to treat osteoporosis. Raloxifene acts the same as estrogen and prevents bone loss. It decreases the fractures' risks and inhibits resorption of bones.
  • Alendronate can reduce osteoplastic bone absorbing activity. Alendronate is a bisphosphonate. It is effective for women who cannot bear estrogen therapy. It helps in the prevention of bone loss in women after menopause.
  • Another drug that helps in decreasing bone resorption is Calcitonin. It is an expensive drug. It has to be taken in the form of injection.
  1. The natural alternative, Ipriflavone

Ipriflavone is a 7-isopropoxy iso-flavone. It is synthesis by isoflavone. It is best for the treatment to suppress the resorption of bone. So, ipriflavone is the best drug to prevent bone resorption than the drugs mentioned above, as it has no side effects. As a result of many types of research, it is proved that ipriflavone can form new bone by stimulating osteoblasts. The only side effects that can occur by injecting ipriflavone is stomach upset in only a small number of patients.

It means not every patient that intake ipriflavone will have upset stomach only a few of them have. Due to no serious side effects, ipriflavone is considered a strong drug for osteoporosis treatment in postmenopausal women and old age people. It is one of the safe and powerful drugs for the prevention of osteoporosis.

Experiments and researches show that ipriflavone show higher activity of bone-building in the body when its intake with other supportive drugs. Ipriflavone is a registered drug for the treatment of osteoporosis in Japan and many countries of Europe. Ipriflavone is an alternative for hormone and other drugs in the treatment of osteoporosis and increases bone mass.

The intake of ipriflavone with some dose of estrogen can increase anti-osteoporotic effects. Thus proved that ipriflavone is better than other synthetic drugs. It is cheap, easily available, and has fewer side effects than other drugs such as Calcitonin, sodium fluoride, Raloxifene, and Alendronate. Ipriflavone is a naturally occurring drug, and it cost very less amount to make ipriflavone from iso-flavone.

  1. Ipriflavone and vitamin D

Vitamin D performs the function of absorption of calcium from the gut to the bones' resorption. The calcium is an essential nutrient of bones. Calcium makes the bone strong. The deficiency of calcium can cause many bone diseases, including osteoporosis—Vitamin D plays a major role in the absorption of calcium in bones. So deficiency of vitamin D can lead to the development of osteoporosis in the body. The liver metabolizes vitamin D in the body. The failure of metabolizes of vitamin D in the liver is also the main cause of deficiency of calcium in bones.

The intake of both vitamin D and ipriflavone can act more effectively and efficiently for increasing bone density. Results of experiments show that bone-building activity accelerates when ipriflavone and vitamin D3 are taken together compared to the single injection of ipriflavone. The injection of vitamin D3 alone also does not affect. The combination of both increased the mineral density of the bone in the full length of the femur.

It was found out that vitamin D3 and ipriflavone proves effective is halting of loss of bones in postmenopausal women. The average loss of bone by injection of the combination of vitamin D3 and ipriflavone was only 0.33 %. In contrast, the loss of bone was 2.37 % when ipriflavone was injected alone, and bone loss for vitamin D3 alone group was 1.15 %.

  1. Ipriflavone complex supports maximum bone building

To prevent osteoporosis and to have maximum bone rebuilding in the body, the ipriflavone complex can prove effective. Ipriflavone complex includes calcium MCHC, vitamin K, vitamin D, vitamin D3, and many other bone supportive supplements such as magnesium, zinc, and calcium.

Ipriflavone will also be effective for the treatment of periodontal diseases. The processes which lead to osteoporosis are the same as those which lead to periodontal diseases. So ipriflavone can also treat periodontal diseases.

  1. Calcium and ipriflavone

If ipriflavone intake with calcium supplements, then their combination will make stronger bones. This combination of ipriflavone and calcium will also maintain the bones to be strong. Calcium is the main nutrient of bones, which keeps them stronger.

Due to a deficiency of calcium, bones become weak and can degrade easily. The metabolism of calcium is improved by ipriflavone. Ipriflavone bind itself with the binding sites available at mature osteoclasts and precursor cells to increase the metabolism of calcium. Osteoclasts cells are those who digest bone. Due to the binding of ipriflavone with osteoclasts cells, a bone calcium flux altered and its deceased the resorption of bone.

A study of 2 years revealed the effects of ipriflavone bone-building spine in postmenopausal women who have a low density in vertebral bone. The women took 200 mg of ipriflavone with one gram of calcium three times a day.

After six months of these intake of ipriflavone and calcium combination, the density of these women's spinal bone increases by 1.4 %. The women placed in placebo who only consumed calcium and placebo, their density of bone decreased by 1.2 % in 2 years. The women who recently become menopausal decreased their bone density by 4.9 % during the second year. The study's result was the most rapid loss of bone density experienced during the first five years of menopause.

Ipriflavone can stop bone loss, which occurs shortly after menopause. An experiment examined this ability of ipriflavone. In the experiment, about 50 postmenopausal women with low density in vertebra bone inject 200 mg of ipriflavone three times daily along with calcium. The other postmenopausal women received a placebo. After two years, the result shows that women who intake both ipriflavone and calcium experience no loss in vertebral bone density.

  1. Ipriflavone have stronger actions than calcitonin

Many researchers compared the actions of ipriflavone with FDA approved osteoporosis treatment hormone called Calcitonin. Researchers conducted many experiments to find out which one is ideal for the treatment of osteoporosis. Those experiments show that ipriflavone has a greater ability to resorption bones and inhibit the formation of bones.

Ipriflavone also has greater power to stimulate the osteoblasts to form the new bone cells. These results prove that ipriflavone in stronger in actions then calcitonin hormone. Ipriflavone has no serious side effects, while Calcitonin found to have more serious side effects on the human body.

  1. Ipriflavone and vitamin K

The human body requires vitamin K to convert inactive proteins of bone called osteocalcin into an active form that supports calcium into bones. Vitamin K plays many essential roles, such as halting osteoclasts' actions, which leads to preventing the formation of new osteoclasts. Vitamin K also plays an important role in the metabolism of bones.

The combination of ipriflavone and vitamin K leads to better functioning and mobility of bones. Experiments on actions of vitamin K on bones show that it has the same inhibitory effect on resorption of bones as ipriflavone. Still, the mechanism of both ipriflavone and vitamin D is different. The combination of ipriflavone and vitamin K acts effectively on the prevention of resorption of bones.

Precautions and side effects of ipriflavone

Ipriflavone is a safe drug if it intakes with proper supervision and on the advice of a doctor. It does not have any serious side effects. It is suitable for most people. Some of the side effects of ipriflavone are:

  • Dizziness
  • Stomach pain
  • Diarrhea

Some research demonstrated that ipriflavone could cause decreased white blood cells if the patient takes it for longer, like six months or more. The decreased in the number of white blood cells is called lymphocytopenia. So it is required that the number of white blood cells is monitored in patients taking ipriflavone for a longer time.

Following precautions should be taken

  • Weak immune system

 It is recommended that people having a weak immune system should not intake ipriflavone without consulting with a physician. The intake of ipriflavone decreases white blood cells, which affects the immunity of the body. The immunity of the body decreases by a higher intake of ipriflavone. If one's immune system is already weak, he/ she will intake ipriflavone for a longer period; then, his/ her body will lose the ability to fight off infections.

  • Lymphocytopenia

As mentioned above, ipriflavone affects the number of white blood cells in the body, so it is concerned that longer and higher uptake of ipriflavone can cause lymphocytopenia or it might affect the pre-existing lymphocytopenia.

  • Breastfeeding and pregnancy

 It is not safe to use ipriflavone during pregnancy or post-pregnancy. It can affect the breastfeeding of a mother. So it is recommending that it should be avoided during pregnancy.

Dosing of ipriflavone

It is recommended that the dosing of ipriflavone should be followed, as suggested by your doctors. As a result of a scientific study following doses are studied for uptake:

  • After postmenopausal treatment of weak bones, 200 mg of ipriflavone three times a day will be best.
  • 600-1200 mg daily uptake of ipriflavone will be okay for the treatment of Paget's disease.
  • For the treatment of renal osteodystrophy, 400 to 600 mg of ipriflavone daily should uptake.

Tips for up taking the ipriflavone

The procedure that should be followed for the intake of ipriflavone is the same as other medicine. However, the following things should be followed while in taking pills of ipriflavone:

  • Never take ipriflavone without consulting from a doctor.
  • Always take medicine prescribed by the doctor.
  • Take the right amount of medicine as prescribed by your physicians at the right time.
  • If the medicine is not showing the effective result or are still feeling the pain of osteoporosis, consult it again.
  • Never take ipriflavone during pregnancy. However, if your doctor suggested them, then take it in less amount.
  • Keep the medicine at room temperature and far from the approach of children.

Conclusion

It has been concluded that ipriflavone is a drug that is synthesized from iso-flavone hormone found in soy plants. Ipriflavone has the same chemical structure as estrogen. Ipriflavone drug increases the calcium absorption in bone and decreases the breakdown of bones. Ipriflavone is used mostly for the treatment of osteoporosis in postmenopausal women.

 It relieves the pain caused by osteoporosis and makes the bones stronger. Ipriflavone combination with different bone supporting elements such as ipriflavone combination with calcium, ipriflavone with vitamin K, and it’s with vitamin D3 increases its activity, becoming more effective when patient inject it with these bone supporting elements. The combination of ipriflavone with bone supporting element is called the ipriflavone complex.

It prevents loss of strength of bones, stimulating action of osteoblasts and improves the effect of estrogen to prevent osteoporosis. When ipriflavone is used with estrogen, it allows fewer estrogen doses to be used in postmenopausal women. The main uses of ipriflavone drugs are in preventing and treating weak bones in postmenopausal women. It helps in the reduction of pain associated with osteoporosis. 

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