Health Benefits Of Calcium D Glucarate

Posted by Wen Dan Jiang on

Health Benefits of Calcium D Glucarate

Calcium D-Glucarate is a calcium salt prepared by mixing calcium and glucaric acid, a chemical compound present naturally in your body and foods  such as oranges, apples, and broccoli, etc. it is incredibly beneficial for preventing specific kinds of cancer. It is thought to reduce your body's hormone estrogen levels, supporting your defense against hormone-dependent cancers, like skin and prostate cancers. Additionally, calcium D-glucarate may be helpful in detoxification by removing cancer-causing agents, toxic chemicals, and steroid hormones from your body. The designated benefits of this supplement come from the D-glucarate, not from the calcium.

Several studies recommend that calcium D-glucarate may help prevent certain cancers. Calcium D-glucarate may lower estrogen levels, which is thought to be beneficial in treating some individuals with hormone-dependent cancers.

However, most of the findings come from lab research and animal-based research. Human studies are limited, and we require proving multiple benefits of calcium D-glucarate.

In this article, we will discuss the health benefits of Calcium D glucarate and all other relevant details.

What Is Calcium D-Glucarate?

The name of the chemical makes you think that it is associated with bone health as calcium is an essential mineral in regulating healthy bones. But this compound does not have anything to do with improving bone health or density. On the other hand, this chemical is often utilized in the management of toxic substances in your body. There is also scientific proof that associates with a decreased risk of cancer.

It is a special kind of D-glucaric acid. Mainly, it is a calcium salt that you derive from glucaric acid. We can also call it calcium glucarate. D-glucaric acid is a natural chemical. Your body makes small quantities of this chemical naturally. Certain varieties of fruits and vegetables comprise small quantities of glucaric acid.

Grapefruit, orange, and apple have the most significant concentrations of glucaric acid. Cruciferous veggies, like spinach, or kale, are also renowned for being rich in this chemical.

There are medicinal usages for Calcium D-glucarate. Oral supplementation is sometimes offered to patients. It may facilitate some conditions and is known to be helpful in the detoxification process of your liver.

How Do Calcium D-Glucarate Work in Your Body?

There is a potential link between specific steroid hormones and the risk of cancers. Individuals must understand how Calcium D-Glucarate may affect these hormones. There is mainly an influence on estrogen in your body when the chemical is utilized.

The impacts may not be as significant when getting glucaric acid from fruits or vegetables. The human-made chemical Calcium D-Glucarate is highly efficient at minimizing levels of estrogen in the patient. It offers an improvement in the maintenance of particular hormones in your body.

How Is Calcium D-Glucarate Prepared?

It is significant to know that Calcium D-Glucarate is not your natural chemical. Glucaric acid is present naturally in certain foods, as well as in the human body. Calcium D-glucarate, however, is a chemical prepared in a laboratory setting.

Calcium is joined with glucaric acid to form Calcium D-glucarate. The chemical is then utilized to make medicine. The medicine may be recommended to a patient in specific conditions.

Beneficial Usage of Calcium D-Glucarate

  • In a medical case, doctors utilize Calcium D-Glucarate for particular reasons. When patients may get an advantage from it, they may prescribe the patient with a regular dose of this chemical.
  • Most of the times; Calcium D-Glucarate will be provided to patients suffering from specific cancers. Most of these cases apply to people with hormone-dependent cancer. Your physician may also recommend a patient with its supplementation. It is the particular situation when this person is at higher risk for these cancers.
  • A medical healthcare provider may also tell a person to utilize Calcium D-glucarate to minimize high estrogen levels. In males, it may aid in preventing risks of estrogen dominance.
  • There are also scenes where it may be utilized as a lipid-lowering agent. Some studies have discovered that it may minimize levels of LDL cholesterol. In one recent research, subjects feel a decrease in LDL cholesterol of up to 36 %. Total cholesterol also reduced by 10% to 15% in the study subjects.

Health Benefits of Calcium D Glucarate 

Certain studies have shown the potential effects of Calcium D-Glucarate in your body. The majority of these studies consider the preventative impacts the chemical may have on certain cancers. Other advantages have been described too.

Here, it would be significant to consider the mechanism of action associated with the chemical. In the digestive system, Calcium D-Glucarate is transformed into a compound called D-glucaro-1, 4-lactone. It is a critical compound that suppresses the activity of an enzyme associated with specific adverse effects in your body. The enzyme is called beta-glucuronidase.

The enzyme beta-glucuronidase has been associated with insufficient detoxification function by the liver. It may enhance free radicals in your body. The enzyme also leads to more toxic chemicals to re-enter your blood circulatory system from the liver. It is one way that your risk of cancer and other conditions associated with toxins can be maximized.

An individual may also find that it can protect their blood proteins efficiently. The product may also be beneficial in minimizing the build-up of toxins from pharmaceutical medicines. Environmental toxins may also be decreased.

Below are the particular health benefits of Calcium D-glucarate;

  1. Detoxification of Liver

Glucaric acid is the best supplement present in our body for detoxification. There is no proper supplement that can provide glucaric acid to our body to meet the need of glucaric acid in our body. An oral dose of calcium d glucarate is taken to have the required amount. One of the significant features of the calcium d glucarate over glucaric acid is that it can detoxify for a longer duration.

In several studies, it has been observed that glucaric acid only detoxify liver for 1 hour, whereas calcium d glucarate does the same but for 5 hours. Glucaric acid is present in our body that reaches the stomach and combines it with the toxins. These toxins are then removed from the body via urine.

  1. Removal of Excess Estrogen

Whenever the level of beta-glucuronidase increases in our blood, it increases the number of receptors for estrogen hormone. Due to this, more estrogen is excreted, and it binds more to receptors. An increase in estrogen levels may result in increased growth of tissues. That may give rise to man boobs and the inability to lose body fat. Research says that tamoxifen is a process in which the use of calcium d glucarate decreases the high level of estrogen.

Calcium d glucarate fails excess of estrogen to accumulate in one place. That passes through urine from the body. A Review article in 2003 states that calcium d glucarate is effective in preventing cancer.

Handling of Proteins

The human body has to consume a lot of protein to meet the nutritional values they require. A lot of ammonia is produced in the body, and kidneys and liver have to work hard to detoxify and kick out this material outside the body. Liver and kidneys have to remain engaged every time in fighting against pollutants, chronic infections, and mycotoxins. In such situations, our body doesn't find too much time to convert these proteins to ammonia.

We need something in this case that can automatically detect this protein and detoxify them. Calcium D- glucarate is the best strong element that can handle this without any trigger. Some physicians recommend that if you are consuming a diet that contains almost 25-30% protein, you must have to take a supplement to degrade them.

  1. Maintenance of Cholesterol

Calcium D-glucarate is the natural element available in our body that helps us from the attack of unwanted lipids and fats in our body. These fats and lipids may cause significant blockage at many spots in veins or arteries.

This blockage may lead to any cardiac disease. In this case, calcium D-glucarate helps a lot to prevent us from these diseases. It destroys low-density lipids from our body, which is bad cholesterol and gives rise to HDL cholesterol, which is good cholesterol for our body and immune system. Not only this calcium D-glucarate also helps in the reduction of Triglycerides.

  1. Prevention in Case of Tumours

CDG has been found much effective in the case of many tumors. It is helpful in the case of lung cancer, prostate cancer, and breast cancer. In the case of breast cancer, it prevents the unusual production of estrogen hormone in our body. This inhibition results in inhibition of the stimulation of tumor cells in the breast area. Somehow if breast cancer happens, then it also protects from cell division of the cancerous cell. Indirectly we can call it can cause inhibition in the production of cancerous cells.

Few clinical trials have also been performed to test lung cancer and the effect of CDG on it. It stimulates the removal of cancerous cells and protects our lungs from disease. Not only this enzyme lowers the risk of cancer if a dose of 9 grams a day is delivered to the patients.

  1. Antioxidantseffects

Due to the antioxidants property of this supplement, it helps in the prevention of a lot of diseases. It prevents our platelets from destroying due to oxidation. It also inhibits the action of free radicals on our cells. In some studies, CDG is found to protect the organs of diabetic patients from oxidative damage. However, some insufficient evidence is available of its benefits due to antioxidant property.

It gives us benefits in;

  • Weight loss
  • Hair fall
  • Acne
  • Bodybuilding
  1. Beneficial Against Cancer

Calcium D glucarate is incredibly essential in case of preventing the risk of certain cancers, and different studies support this claim.

Prostate, Breast, and Colon Cancers

A report published in Alternative Medicine Review experts examined the available research on calcium-D-glucarate and discovered that it might prevent beta-glucuronidase, an enzyme-linked to enhanced risk for a variety of hormone-dependent cancers, like breast, prostate, and colon cancers, when it occurs at increased levels.

Skin Cancer

There's also certain scientific proof that calcium D-glucarate may protect against skin cancer. A 2007 study published in the Journal of Environmental Pathology, Toxicology, and Oncology indicated that treating mice with it aided inhibiting the growth of skin cancer by inducing apoptosis.

Although it highlights promise as an anti-cancer agent, there are currently few clinical trials testing its usage in the treatment of certain health conditions.

There are also some scientific test results that calcium D-glucarate may offer protection against skin cancer. In short, calcium D-glucarate is incredibly beneficial in the case of preventing skin cancer.

Lung Cancer

According to a 2006 study published in Oncology Letters showed that it might aid in fighting lung cancer. In tests on mixes, researchers concluded that calcium D-glucarate helped stop the growth of cancerous tumors in your lungs by minimizing inflammation and inducing apoptosis, a type of programmed cell death important for inhibiting the spread of cancer cells.

Sources Of Calcium D-Glucarate

Although Calcium D-Glucarate is sometimes recommended, individuals can purchase the supplement not only from nearly the market or pharmaceutical store, and you can also buy it from online stores.

When it comes to getting enough of the chemical via a natural route, an individual must understand the fact that calcium D-glucarate itself is an artificial chemical. There are still ways to get a similar activity in your body. Focus on the fact that D-Glucarate simply mixes glucaric acid and Calcium.

Some of the foods comprise of glucaric acid. It is focused on the primary component of Calcium D-glucarate. In fact, only 10 % of the chemical comprises elemental Calcium. Therefore, including foods that comprise of glucaric acid to an individual's diet may produce beneficial impacts. It must be conducted in such a way to make sure the person still fulfills their adequate dietary requirements.

Furthermore, the majority of sources for glucaric acid must be fruits and vegetables. It means the foods are already rich in nutrients. Enhancing the consumption of glucaric acid may aid to rid your body of environmentally toxic substances and also toxins from drugs.

It may also be beneficial in the situation of estrogen dominance. High estrogen may be effectively reduced with the maximized consumption of this natural compound.

When the steroid hormone is decreased, there may be a lower risk of specific hormone-dependant cancers. Moreover, the detoxification process may aid in minimizing free radicals in your body. It may also aid to five a reduction in the risk of other cancers, not only those that are linked to hormones.

Is Calcium D-glucarate An Effective Source of Calcium?

The health benefits of this chemical come mainly from its D-glucarate and not from the calcium. The supplement comprises approximately 10 % of elemental calcium. Good sources of calcium are calcium citrate with nearly 20 % elemental calcium, and calcium carbonate, which is approximately 30% elemental calcium.

The calcium's recommended daily allowance is 1,000 mg to 1,200 mg for individuals.

Calcium D-glucarate is an artificial chemical. It is similar to a naturally present chemical known as glucaric acid. It is present in your body and fruits and vegetables such as orange, apple, Brussel sprouts, and cabbage. It is composed by mixing glucaric acid with calcium to make supplements that people use for medicine.

Calcium D-glucarate is utilized to stop breast, lung, and colon cancer; and eliminate cancer-leading agents, harmful chemicals, and steroid hormones from your body.

Because of the insufficient clinical trials and information related to the safety of doses that high, it may not be prudent to consume calcium D-glucarate for cancer prevention or any other critical health issue. If you are considering utilizing it, ensure to discuss it with your doctor or healthcare provider first.

To minimize the cancer risk, speak to your physician about following a balanced diet rich in antioxidant-rich vegetables and fruit, doing workout daily, and keeping your weight in control.

There are also some scientifically proven facts that individuals who drink green tea and maintain healthy vitamin D levels may have a reduced risk of certain kinds of cancer.

Who Should Take Calcium D-Glucarate?

A lot of individuals may benefit from the usage of Calcium D-glucarate. Any individuals who seem to be at higher risk for particular cancers may focus on consuming this kind of oral supplement. Calcium D-glucarate is exceptionally efficient against hormone-dependant cancers. It may generally involve the following cancers; prostate cancer, breast cancer, colon cancer, and skin cancer.

Prostate cancer is the sole issue for the male community. Breast cancer is most common in women, while colon cancer can be in both men and women.

The chemical is not taken as a necessary nutrient. For this reason, there is no enough detail on a deficiency of Calcium D-glucarate. Clinical trials for a deficiency will typically not be done. Therefore, it is not the right thing to offer suggestions for individuals to consume the product if they are deficient in the chemical.

There are also other situations where Calcium D-glucarate may also be beneficial. Males who experience estrogen dominance can get an advantage from their product. It can be offered with oral supplementation of the chemical.

The usage of the chemical may aid in reducing estrogen in your body and restore hormonal balance. In females, estrogen decrease may also aid in preventing complications from hormone-dependent cancer. It is most often the situation with breast cancer in women.

Few steroid hormones may also be minimized with the usage of Calcium D-glucarate. It is also the benefit of it. Particularly when considering the influence of steroid hormones on the risk of cancer.

Interactions of Calcium D-Glucarate With Other Compounds

When you use according to given recommendations, Calcium D-Glucarate may be entirely safe for an individual. It can aid in reducing estrogen in your body. It may also assist in eliminating free radicals and regulating detoxification. 

  • It is a good option for cases where an individual is at risk of skin cancer and prostate cancer etc.
  • In certain situations, however, an individual with estrogen dominance at risk of hormone-dependent cancer may need to look at alternative options. 
  • Specific interactions have previously been linked with the use of Calcium D-glucarate.
  • A critical interaction, for example, is the interaction between Calcium D-Glucarate and alcohol. When alcohol is utilized with the chemical, it may be eliminated from your body at a high rate. It makes the supplementation less favorable for the particular condition. A more significant dose may also be required as the alcohol may minimize the bioavailability of the chemical.
  • Medications that are altered by your liver may also interact with the chemical. These drugs are taken as Glucuronidated medicines. Drugs include Camposarr, Ativan, Valium, Lipitor, Mevacor, and many more.
  • Calcium D-Glucarate may typically be utilized with sulforaphane pills. Additionally, many items tend to mix the two for a more efficient way of detoxifying your liver and minimizing the risk of some kinds of cancers. Both compounds are originated from cruciferous vegetables like Brussel sprouts, kale, and spinach, etc.
  • Few supplements may also interact with Calcium D-glucarate. You have to see a physician before you begin utilizing this chemical as a supplement. The disclosure of both pharmaceutical medicines and dietary supplements must be given to the doctor. The doctor must be able to determine if there may be any severe interactions that the patient should be careful about. Interactions can lead to significant drawbacks.

Possible Side Effects

There isn't enough study for the side effects of calcium D-glucarate; however, it is thought to be safe and well-tolerated in our bodies. Because of the insufficient studies, it must not be consumed by females who are pregnant or breastfeeding their babies.

There is some concern that consuming calcium D-glucarate in unison with specific medications subject to glucuronidation may minimize the efficiency of specific drugs. Some of these drugs include Lipitor (atorvastatin), and Tylenol (acetaminophen). It may also temporarily minimize the levels of other steroid hormones in your body, such as testosterone.

Dosage and Preparation

There is no recommended dose for calcium D-glucarate, and a lot of studies are required to talk about this matter with a guarantee. The human body well-tolerated a 2003 study published in the journal Chest subjects doses between 1 g and 8 g daily.

What to Look For

Calcium-D-glucarate is sold in dietary supplement form in different natural-foods stores, and stores specifically for dietary supplements. You can also buy these pills from online stores.

Dietary supplements are not adjusted by the U.S. Food & Drug Administration. When purchasing calcium D-glucarate see the brand that has been tested by a trusted independent party, like U.S. Pharmacopeia, or ConsumerLab. Don't jump on any of its supplements and always check the best variety and buy it.


Calcium D-glucarate is a derived form of glucaric acid. It is a calcium salt formed by joining calcium and glucaric acid, a chemical compound found naturally in your body. In foods such as oranges, apples, and broccoli, etc. it is incredibly beneficial for preventing particular types of cancer.

Certain health advantages may come with the usage of Calcium D-glucarate. Sometimes, a healthcare provider or physician may prescribe a patient with this medicine. Other benefits of this chemical also present, like in individuals who want to benefit from the preventative effects that the calcium D-Glucarate may have in their body.

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