Does magnesium L Threonate help anxiety

Posted by Wen Dan Jiang on

Does Magnesium L-Threonate Help Anxiety? –

What Is The Role Of Magnesium L- Threonate In Managing The Anxiety? - Magnesium L- Threonate Role in Improved Brain Function

Are you a sufferer of anxiety and stress? Have someone recommended you to use Magnesium L-Threonate for relieve of your anxiety? You may have this question in your head that how does a Magnesium supplement help in relieving some brain-related disorder?

Magnesium L- Threonate is a magnesium supplement developed for brain-related disorders. It specifically targets and enters the brain.

1. Magnesium L- Threonate -How Does It Work?

Magnesium L Threonate is made by chelation. Chelation is a process in which a molecule is joined with magnesium to enhance its bioavailability, stability, and efficacy.

The normal dietary magnesium is unable to reach the brain and the diet of the developed world is somewhat very deficient in magnesium.

It is the second most common deficiency of the industrialized world after vitamin --D.

The main focus of the magnesium L Threonate development was to deliver the required magnesium to the brain. But why the magnesium is so important to the brain?

2. Role of the Magnesium in Brain Functioning

Magnesium plays an important role in managing the signals between your body and brain.

It helps in the proper functioning of N-methyl-D-aspartate (NMDA) receptors, which are important for brain development, memory, and learning.1

The lower level of magnesium leads to the blockage of the NMDA receptor which can affect the functions dependent on them.

3. Magnesium L- Threonate and Its Role in Managing Anxiety

Anxiety is defined as a feeling of worry, nervousness, or unease about something with an uncertain outcome.

Anxiety is a normal phenomenon and is considered a healthy emotion unless you are experiencing it at a disproportionate rate. Then it becomes a medical disorder.

Symptoms of anxiety include an uncontrollable feeling of worry, lack of concentration, restlessness, irritability, and sleeping difficulties.

Anxiety can be dealt with multiple supportive therapies e.g. stress management, relaxation techniques, exercise, etc, and various medications.

Recent studies have investigated the role of magnesium L- Threonate in managing anxiety and depression. Increased serum magnesium level has anti-anxiety effects.2

Intake of dietary magnesium has been linked to lowering anxiety level in a community-based study.3

In 2017, Boyle and Dye reviewed the studies conducted on the management of anxiety and stress in the adult population with magnesium alone and combination. They found the potential positive effect of magnesium in relieving the stress in most of the studies. 4

4. What Other Condition Can Benefit From Magnesium L- Threonate?

Magnesium L- Threonate can help in plenty of brain-related disorders. These include Parkinson’s disease, dementia, bipolar disorder, schizophrenia, Alzheimer’s disease, acute brain injury, addictions, and seizures.

5. What Is The Recommended Dose Of Magnesium L- Threonate?

Magnesium L- Threonate is commonly supplied in 500 mg capsules. The adult recommended dose of this magnesium supplement is 1000 mg to 2000 mg per day. 

2000 mg of Magnesium L- Threonate supplement provides 144 mg of elemental Magnesium. The daily Adult requirement of magnesium is 400 mg.

You should consult first with your doctor before taking magnesium supplements if you are suffering from any intestinal diseases, cardiovascular disease, kidney issues, or diabetes.

6. Take-Home Message

Anxiety disorder shouldn’t be taken lightly as it may lead to depression and other brain-related disorders. It is one of the most occurring psychiatric disorders with a prevalence of 15 % in the general population. 5

A Magnesium-deficient diet is common in the developed world. It is the second most common deficiency after Vit-D in such countries. This deficiency can cause various brain-related malfunctioning.6

There are various magnesium supplements available for different uses. Magnesium L- Threonate is developed keeping in the requirement of crossing the blood-brain barrier. It enters the brain tissue due to its unique formation.

Magnesium element has shown promising results in helping the anxiety patients. Its use as a supplement not only enhances the bioavailability of magnesium to the brain but also covers the daily dietary magnesium requirement



  1. Newcomer JW, Farber NB, Olney JW. NMDA receptor function, memory, and brain aging. Dialogues Clin Neurosci. 2000;2(3):219-232.
  2. Poleszak E, Szewczyk B, Kedzierska E, Wlaź P, Pilc A, Nowak G. Antidepressant- and anxiolytic-like activity of magnesium in mice. Pharmacol Biochem Behav. 2004;78(1):7-12. doi:10.1016/j.pbb.2004.01.006
  3. Jacka FN, Overland S, Stewart R, Tell GS, Bjelland I, Mykletun A. Association between magnesium intake and depression and anxiety in community-dwelling adults: the Hordaland Health Study. Aust N Z J Psychiatry. 2009;43(1):45-52. doi:10.1080/00048670802534408
  4. Boyle NB, Lawton C, Dye L. The Effects of Magnesium Supplementation on Subjective Anxiety and Stress-A Systematic Review. Nutrients. 2017;9(5):429. Published 2017 Apr 26. doi:10.3390/nu9050429
  5. Kessler RC, Aguilar-Gaxiola S, Alonso J, et al. The global burden of mental disorders: an update from the WHO World Mental Health (WMH) surveys. Epidemiol Psichiatr Soc. 2009;18(1):23-33. doi:10.1017/s1121189x00001421
  6. Magnesium-

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