does magnesium l-threonate cause diarrhea

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Does Magnesium L-Threonate Cause Diarrhea? - What Is Magnesium L- Threonate? What Is The Safe Dose Of Magnesium L-Threonate?

Does the use of magnesium L- Threonate cause diarrhea? Am I using the right amount of magnesium L-Threonate for boosting my memory? If you have been using the magnesium L- Threonate as a dietary supplement for dementia or other brain disorder, you may often have these questions in your head.

Unlike other magnesium supplements, Magnesium L Threonate was developed for a different function. This was developed to be absorbed by the body to cross the blood-brain barrier, not to retain in the intestine to pull water so the chances of developing diarrhea are less.

Magnesium L-Threonate is a uniquely structured Magnesium Supplement targeted to enter the brain. But why Magnesium is vital for brain activities?


1. Importance of Magnesium for Brain Functioning

Magnesium is an essential mineral required by the body. It is one of the abundant electrolytes found in the body.

Magnesium is so significant for wellbeing that it's been known as the Master mineral. It's especially important for proper brain functioning and nervous tissues.

Magnesium, a cofactor for approximately 300 enzymes, plays a diverse role in the biological processes which include protein metabolism, nerve and muscle function, blood pressure control, and glycemic control of the body. It is required for energy production and breaks down glucose. 1, 2

2. Why Is Magnesium L- Threonate Different From Other Magnesium Supplements? 

Magnesium L-Threonate is a chelated magnesium product. Chelation is a process that binds the magnesium mineral to other molecules.

 By this process, the bioavailability, absorption, and the stability of the magnesium is enhanced.3

It is a nutritional supplement used to achieve the required value of magnesium in the body. The second most deficient mineral in the developed world is magnesium and its deficiency is common in the western diet. It is linked to various conditions e.g. numbness, tingling, muscle contractions and cramps, seizures, personality changes, abnormal heart rhythms, and coronary spasms. 4, 5

3. How Does Magnesium L –Threonate Work?

Magnesium plays a vital role in normal brain functions but the bad news is that it can’t cross the blood-brain barrier easily.

Magnesium L-Threonate was developed primarily focusing on this need. It can easily cross the blood-brain barrier so the bioavailability to the brain tissue is enhanced.

Magnesium has an important role related to certain brain disorders, which include;

  • Parkinson’s disease
  • dementia
  • bipolar disorder
  • schizophrenia
  • Alzheimer’s disease
  • Anxiety
  • acute brain injury
  • addictions
  • seizures

4. What Is The Normal Dose Of Magnesium L-Threonate?

This supplement is supplied usually in capsule form which contains 500 mg of Magnesium L-Threonate.

The recommended adult dose of Magnesium L-Threonate is 1000mg to 2000mg (2 to 4 Capsules). 2000 mg dose of this supplement provides 144mg of elemental magnesium.

5. What Are The Benefits Of Magnesium L-Threonate?

  • Increases bio-availability of magnesium- Fulfills the daily requirements of the magnesium
  • Memory enhancement and better cognitive functions
  • It Supports healthy sleep and it helps in relaxation

Magnesium L-Threonate crosses the blood-brain barrier and benefits the patients of dementia. 6

6. Can Magnesium L-Threonate Cause Diarrhea? What Are The Other Possible Side Effects?

Many magnesium products are used for the laxative purpose but the magnesium L- Threonate lacks this property. So the chances of having a laxative effect leading to diarrhea are negligible.

Other side effects of the magnesium L Threonate that may occur are headache, increased blood to the brain, and drowsiness.

7. Who Should Be Cautious While Using Magnesium L-Threonate?

People with the following disease should take magnesium supplements after taking advice from their physicians. 7

  • Intestinal disease
  • Diabetes
  • Cardiovascular disuse
  • Kidney disease

8. The Bottom Line

The latest developed Magnesium supplement and its ability to enter the brain has enabled more availability of magnesium to the nervous tissues. This, in turn, enhances brain functionality.

The patients with disease due to malfunctioning of brain e.g. dementia, Alzheimer's disease, Schizophrenia, brain injury, anxiety are greatly benefiting from this.

Our routine diet is significantly deficient in supplying the right amount of magnesium to the body. Therefore, Magnesium supplements of various types are available in the market each having its benefits.

The daily recommended dose of Magnesium L- Threonate is 1000mg to 2000mg. 2000mg of the dose equals to 144mg of elemental magnesium. One shouldn’t use it in overdoses and if you have some underlined disease that may get aggravated due to magnesium supplements; you must talk to your doctor first.  


  1. Institute of Medicine (IOM). Food and Nutrition Board. Dietary Reference Intakes: Calcium, Phosphorus, Magnesium, Vitamin D and Fluoride. Washington, DC: National Academy Press, 1997.
  2. Rude RK. Magnesium. In: Ross AC, Caballero B, Cousins RJ, Tucker KL, Ziegler TR, eds. Modern Nutrition in Health and Disease. 11th ed. Baltimore, Mass: Lippincott Williams & Wilkins; 2012:159-75.
  3. Chelated Minerals-
  4. Rude RK. Magnesium. In: Coates PM, Betz JM, Blackman MR, Cragg GM, Levine M, Moss J, White JD, eds. Encyclopedia of Dietary Supplements. 2nd ed. New York, NY: Informa Healthcare; 2010:527-37
  5. Magnesium-
  6. Sun, Qifeng, et al. "Regulation of structural and functional synapse density by L-Threonate through modulation of intraneuronal magnesium concentration." Neuropharmacology 108 (2016): 426-439.
  7.  Magnesium-

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