Can I take Forskolin With Artichoke Extract?

Forskolin

Forskolin or Coleonol is a naturally occurring chemical substance obtained from the roots of the Indian Coleus plant, Coleus forskohlii. It Belongs to the diterpene family. It is a mint-like herb, cultivated to Nepal, India, and few areas of Southeast Asia. It has great importance in Ayurvedic traditional medicine systems and in Folk medicine. It is derived from the geranylgeranyl pyrophosphate (GGPP). It has unique functional elements that includes a tetrahydropyran ring. Yep Forskolin is commonly used to increase the levels of cAMP ”cyclic adenosine monophosphate” by activating adenylate cyclase. In modern science, it has been proven that taken forskolin supplements can be beneficial for your fitness. It aids weight loss by helping mechanisms to create enzymes in the body called Lipase, an enzyme used to catalyze the hydrolysis of fats. It contains adenylate cyclase, an enzyme responsible for performing all key regulatory functions of cells.

Health benefits

It is used as a natural remedy for the treatment of glaucoma, intestinal ulcer, insomnia, cancer, and convulsions. Few clinical researches indicate weight reduction and asthma prevention characteristics.

For weight loss:

It has been suggested by research that taken forskolin supplements may aid in weight loss and building of muscles. In some clinical trials, forskolin helps to lose more body fats. It increases testosterone levels, a male sex hormone that is used to increase muscle mass and bone mass in the body.

For asthma prophylaxis:

Forskolin is used as a folk remedy for asthma management. It mimics the action of certain conventional drugs of asthma. It helps by Boosting the levels of an endogenous molecule called cyclic AMP. It Help in relaxing the muscles around bronchial tubes to make satisfactory breathing.

For the treatment of glaucoma:

It may relieve pressure in the eyes, as in the case of glaucoma. Consider as a safe alternative to beta-blocker in patients having glaucoma with linked asthma.

Dosage:

100-300 mg/day extract by mouth containing 10-20% forskolin.

Artichoke

The globe artichoke also called by the name French artichoke and green artichoke in the united states. They are largely unopened flowers. It has a variety of species cultivated as food among the Greeks and Romans. The edible portion of the artichoke is a flower bud before bloom. Artichoke does not contain great nutritional value, but they contain minor quantities of many vital minerals and vitamins that are used as supplement other than the food. As a food, it is served as an appetizer or as a salad with other fresh vegetables. Artichoke can also be used in herbal tea, produces a commercial product in many regions of southeast Asia. Cynardoside, scolymoside, luteolin, inulin, and chlorogenic acid are considered as bioactive’s principle of artichoke. It provides important minerals like calcium, iron, potassium, phosphorus, and chromium.

Health benefits

Artichoke extract has a concentration of different compounds, having distinctive pharmacological effects include: luteolin, responsible for the inhibition of cholesterol synthesis. Inulin, from artichoke, has a potent prebiotic and probiotic effects. Chlorogenic acid and cynaroside have significant action in vascular endothelial functions.

Cholesterol-lowering effects:

Artichoke extract is beneficial to reduce serum cholesterol and triglyceride levels. Inhibit the development of atherosclerotic plaque. Decrease cholesterol synthesis by inhibiting the action of an enzyme HMG-CoA reductase, the same mechanism as statins. Reduce the concentration of LDL, low-density lipoprotein that exists as bad cholesterol in the blood.

Antioxidants effects:

Artichoke is a good source of antioxidants including vitamin C, flavones, and hydroxycinnamic acid. The Antioxidant act as a scavenger in the body that remove free radicals from the body. The inhibition of LDL is also promoted by the antioxidant activity. The hepatoprotective effect is also demonstrated further antioxidant properties.

Cardiovascular protection:

Artichoke may have vasodilatory properties and give strength and protection to the vascular system. It acts by promoting the enzyme eNOS, which plays an active role in the widening of blood vessels. It helps to regulate blood pressure.

Improve liver health:

Artichoke increases the production of bile, that remove toxins from the liver. Cynarin and silymarin are compounds found in artichoke leaves that has powerful antioxidant property, helps the liver to generate healthy tissues.

Dosage:

Between 320-1800mg OD, per day

Forskolin with Artichoke extract

Forskolin and Artichoke extract is an extremely popular combination in the past years. This combination was first introduced by Abelard Lindsay. These two herbs, when used in combination produce synergistic effects. Forskolin produces a vital role by stimulating the ATP, adenosine triphosphate enzyme. When combined with the inhibitory action of artichoke extract, these memory-boosting actions are increased, resulting in a very beneficial and powerful supplement for intelligence and learning. These are being the new area of interest for brain supplements. Forskolin and Artichoke supplements are advantageous to increase motivation levels. Enhance mood and increase the capacity to focus and study. Artichoke and forskolin together increase cAMP levels, which inhibit phosphodiesterase-4 enzymes. This inhibitory effect impacts cognition with improvements like attention, information processing, and memory. They are used in combination to produce a synergistic effect to treat, manage, and prevent several diseases. That includes:

• Asthma.
• Glaucoma.
• Cardiovascular diseases.
• Liver impairment.
• Obesity.
• Bowel syndrome.

References:

Doorn, J., Siddappa, R., Van Blitterswijk, C. A., & De Boer, J. (2012). Forskolin enhances in vivo bone formation by human mesenchymal stromal cells. Tissue Engineering Part A, 18(5-6), 558-567.

ESPINOSA, D. Forskolin Health Benefits.

Lindsay, A. CILTEP™ WHITEPAPER.

Zafar, J. Health Benefits of Forskolin.