10. why should i take msm with glucosamine chondroitin

Posted by Wen Dan Jiang on

Why Should I Take MSM With Glucosamine And Chondroitin?

Benefits of Using the Combination of MSM with Glucosamine and Chondroitin

Why should I take MSM (methyl sulfonyl methane) with glucosamine and chondroitin? The use of MSM with glucosamine and chondroitin is powerful because it creates a strong anti-inflammatory and analgesic effect.


The patients who are taking MSM with glucosamine and chondroitin are getting better relief. The swelling and pain-relieving effect is more powerful and rapid if you use this combination.1

But do you want to know other advantageous effects of these amazing supplements?

Let’s go through them.

1. MSM, Glucosamine, Chondroitin and Their Role On In Managing Osteoarthritis

As stated earlier, MSM, glucosamine, and chondroitin relieve pain and swelling separately as well as when used in combinations.

This combination is greatly beneficial to the osteoarthritis patients.

1.1 Osteoarthritis

It is a degenerative disease affecting approximately 15% of the total population in the world. 2

It is a chronic condition that strikes mostly the elder and hits the females three times as compared to males.

The targeted areas of this disease are mostly knee and hip joints. It is a constant regressive disease of joints which results in decreased joint space, loss of fluid and cartilages, and friction leading to severe pain and inflammation.

1.2 What Is MSM (Methyl Sulfonyl Methane)?

MSM stands for methyl sulfonyl methane and it is a renowned dietary supplement, mostly used in osteoarthritis and is made up of non-metallic sulfur. It exists both in crystalline and as well as the liquid phase. 

It has anti-inflammatory and antioxidant effects.

1.3 How Glucosamine Battles Inflammation?

It is a naturally occurring compound in the body and found in the fluid around joint spaces. Supplemental glucosamine can be prepared in the laboratory or from other natural sources e.g. shellfish.

In some experimental studies, glucosamine has shown protective effect on the cartilage. It points toward the possibility that it can assist in the reduced cartilage shedding, a key driver of worsening osteoarthritis condition. 4

Several studies have proved that glucosamine boosts anti-inflammatory effects by inhibition of inflammatory mediators. So glucosamine intra-discal injection has been proposed for the treatment of chronic discogenic low back pain.

The immediate effect of glucosamine on disc cells needs further studies.

1.4 How Chondroitin Reduces Inflammation?

Chondroitin sulfate is widely allocated in the extracellular matrix and at surfaces of the cell.

There are many pieces of evidence which sport the anti-inflammatory effects of chondroitin. The chondroprotective compound can inhabit many inflammatory processes.

It suppresses oxidative stress-induced apoptosis and diminishes the inflammatory response by degeneration of mediator-induced joint cartilage.

It results in vanquishing inflammation, pain, and swelling. Synergistic effects can be observed if it is used with omega-3 fatty acids and some antioxidants.3

2. How to Use MSM with Glucosamine and Chondroitin? What Is The Recommended Dosage?

  • Normal dosage is 1500mg for glucosamine sulfate and 1200mg for chondroitin sulfate, taken once daily. (MSM usually in lesser quantities) 
  • If Wight is less than 100 lbs, the dose is decreased to 1000mg for glucosamine sulfate and 800mg for chondroitin sulfate.
  • Reported recovery (e.g. decline in painful signs) ranges from three to eight weeks.
  • A few studies have revealed continued improvement of signs after oral consumption was discontinued.
  • Patients should have a record of their symptoms when therapy begins to better assess any differences in pain level or joint mobility, and this data should be shared with their physician.

3. Who Should Be Cautious While Using These Supplements?

Contact your physician if you any of the following conditions. 4

  • A pregnant or breastfeeding mother
  • Allergic to any ingredient especially to seashells
  • Taking medication for diabetes, glaucoma, or warfarin use
  • Any underlined medical issue 
  • If you are under 18

4. The Bottom Line:

MSM, glucosamine, chondroitin and their combination give an analgesic and anti-inflammatory effect in patients suffering from osteoarthritis.

They show greater efficacy in reducing joint pain, swelling around joints and also improve the mobility of joints hence giving tremendous relief to patients.

Patients seem to be more satisfied after using MSM in combination with glucosamine and other combination. Therefore, it is highly recommended combination for the patients struggling with arthritis.


  1. Usha, P. R., and M. U. R. Naidu. "Randomised, double-blind, parallel, placebo-controlled study of oral glucosamine, methylsulfonylmethane, and their combination in osteoarthritis." Clinical drug investigation 24.6 (2004): 353-363.
  2. Stuber, Kent, Sandy Sajko, and KevynKristmanson. "Efficacy of glucosamine, chondroitin, and methylsulfonylmethane for spinal degenerative joint disease and degenerative disc disease: a systematic review." The Journal of the Canadian Chiropractic Association 55.1 (2011): 47.
  3. Jerosch, Jörg. "Effects of glucosamine and chondroitin sulfate on cartilage metabolism in OA: outlook on other nutrient partners especially omega-3 fatty acids." International Journal of rheumatology 2011 (2011).
  4. The Truth About Glucosamine and Chondroitin Sulfate- https://www.oaph.com/patient-resources/education/truth-about-glucosamine-and-chondroitin-sulfate

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